Lead and δ-Aminolevulinic Acid Dehydratase Polymorphism: Where Does It Lead? A Meta-Analysis
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چکیده
منابع مشابه
Lead and δ-Aminolevulinic Acid Dehydratase Polymorphism: Where Does It Lead? A Meta-Analysis
BACKGROUND Lead poisoning affects many organs in the body. Lead inhibits delta-aminolevulinic acid dehydratase (ALAD), an enzyme with two co-dominantly expressed alleles, ALAD1 and ALAD2. OBJECTIVE Our meta-analysis studied the effects of the ALAD polymorphism on a) blood and bone lead levels and b) indicators of target organ toxicity. DATA SOURCE We included studies reporting one or more o...
متن کاملHUMAN GENOME EPIDEMIOLOGY (HuGE) REVIEWS δ-Aminolevulinic Acid Dehydratase Genotype and Lead Toxicity: A HuGE Review
The ALAD gene (chromosome 9q34) codes for δ-aminolevulinic acid dehydratase (ALAD) (E.C. 4.2.1.24). ALAD catalyzes the second step of heme synthesis and is polymorphic. The ALAD G177C polymorphism yields two codominant alleles, ALAD-1 and ALAD-2, and it has been implicated in susceptibility to lead toxicity. Genotype frequencies vary by geography and race.The rarer ALAD-2 allele has been associ...
متن کاملblood lead level and δ-aminolevulinic acid dehydratase activity in pre-menopausal and postmenopausal women
to describe the relationship of blood lead levels (bll) and blood, δ-aminolevulinic acid dehydratase(alad) activity and haematocrit value(hct) to menopause , were examined 17 pre-or perimenopausal (prem) and 17 postmenopausal women (posm)from prishtina city, the capital ofrepublic kosovo. the mean age of the prem women was 28.8 years (21-46), with a mean blood lead level of 1.2 μg/dl (sd=0.583 ...
متن کاملDelta-aminolevulinic acid dehydratase (ALAD) polymorphism in lead exposed Bangladeshi children and its effect on urinary aminolevulinic acid (ALA).
BACKGROUND AND OBJECTIVE Lead has long been recognized as a harmful environmental pollutant. People in developing countries like Bangladesh still have a higher risk of lead exposure. Previous research has suggested that the delta-aminolevulinic acid dehydratase (ALAD) genotype can modify lead toxicity and individual susceptibility. As children are more susceptible to lead-induced toxicity, this...
متن کاملMechanism of renal lead-binding protein reversal of delta-aminolevulinic acid dehydratase inhibition by lead.
The bioavailability of lead in kidney is mediated in part by binding to endogenous high-affinity cytosolic lead-binding proteins (PbBP), which are not detectable in liver. Addition of semipurified 11,500 dalton PbBP to liver delta-aminolevulinic acid dehydratase (ALAD) reaction mixtures reverses inhibition of this enzyme by lead and thus provides an explanation for the relative insensitivity of...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2007
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.9448